For research use only. Not for therapeutic Use.
JK-184（Cat No.:I003124）is a selective inhibitor of the enzyme soluble epoxide hydrolase (sEH), which plays a role in the metabolism of epoxyeicosatrienoic acids (EETs), important lipid mediators involved in inflammation, vasodilation, and tissue repair. By inhibiting sEH, JK-184 increases the levels of EETs, which have beneficial effects on cardiovascular health, including reducing blood pressure and improving endothelial function. JK-184 has been studied for its potential therapeutic applications in conditions like hypertension, atherosclerosis, and inflammatory diseases. Ongoing research aims to evaluate its clinical efficacy and safety for treating cardiovascular and metabolic disorders.
| Catalog Number | I003124 |
| CAS Number | 315703-52-7 |
| Synonyms | N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-amine |
| Molecular Formula | C₁₉H₁₈N₄OS |
| Purity | ≥95% |
| Target | Hedgehog |
| Solubility | 10 mM in DMSO |
| Storage | Store at +4C |
| IUPAC Name | N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-amine |
| InChI | InChI=1S/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22) |
| InChIKey | ROYXIPOUVGDTAO-UHFFFAOYSA-N |
| SMILES | CCOC1=CC=C(C=C1)NC2=NC(=CS2)C3=C(N=C4N3C=CC=C4)C |
