JK-P3

• CAT Number: I014419
• CAS Number: 942655-44-9
• Molecular Formula: C18H17N3O3
• Molecular Weight: 323.35
• Purity: ≥95%
• Synonyms: JK-P3, 3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide;3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide
• Target: VEGFR
• Solubility: Soluble in DMSO
• IUPAC Name: 3,4-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)benzamide
• InChI: InChI=1S/C18H17N3O3/c1-23-15-9-8-13(10-16(15)24-2)18(22)19-17-11-14(20-21-17)12-6-4-3-5-7-12/h3-11H,1-2H3,(H2,19,20,21,22)
• InChIKey: QAZJUVDICQNITG-UHFFFAOYSA-N
• SMILES: O=C(NC1=NNC(C2=CC=CC=C2)=C1)C3=CC=C(OC)C(OC)=C3

JK-P3(CAT: I014419) is a novel pyrazole-based inhibitor of VEGFR-2, with an IC₅₀ of 7.8 μM. It selectively inhibits VEGFR-2-mediated angiogenic signaling, effectively blocking wound healing and tube formation in HUVEC (human umbilical vein endothelial cells) without affecting endothelial cell proliferation. While JK-P3 also inhibits FGFR 1/3 kinase activity in vitro, it shows no significant impact on FGFR signaling in cell-based assays. This unique profile makes JK-P3 a valuable tool in angiogenesis research, particularly for studying VEGFR-2-dependent pathways in tumor growth and vascular development. It provides critical insights into therapeutic strategies targeting pathological angiogenesis in cancer and other vascular disorders.