For research use only. Not for therapeutic Use.
JNJ-1289 is a potent, selective, competitive and allosteric human spermine oxidase (hSMOX) inhibitor (IC50: 50 nM). JNJ-1289 can be used in the research of polyamine catabolism, inflammation and cancers[1].
JNJ-1289 (0.1 nM-1 μM, 0 and 2 h) inhibits hSMOX activity in a time-dependent manner[1].
JNJ-1289 initially forms a weak complex with hSMOX with an apparent Ki value of 1.4 μM, followed by a relatively slow protein isomerization that forms the final tightly bound inhibitor-enzyme complex[1].
| Catalog Number | I043302 |
| CAS Number | 792898-18-1 |
| Synonyms | 4-[(4-imidazo[1,2-a]pyridin-3-yl-1,3-thiazol-2-yl)amino]phenol |
| Molecular Formula | C16H12N4OS |
| Purity | ≥95% |
| InChI | InChI=1S/C16H12N4OS/c21-12-6-4-11(5-7-12)18-16-19-13(10-22-16)14-9-17-15-3-1-2-8-20(14)15/h1-10,21H,(H,18,19) |
| InChIKey | NAJHZKDVMWYLOU-UHFFFAOYSA-N |
| SMILES | C1=CC2=NC=C(N2C=C1)C3=CSC(=N3)NC4=CC=C(C=C4)O |
| Reference | [1]. Elsie Diaz, et al. B Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor. Commun Biol. 2022 Aug 5;5(1):787. |
