For research use only. Not for therapeutic Use.
Potent and selective dopamine D2 receptor antagonist; centrally acting and fast-dissociating ligand; potentially an antipsychotic agent
| Catalog Number | I007433 |
| CAS Number | 935776-74-2 |
| Molecular Formula | C17H17F5N4.2HCl |
| Purity | ≥95% |
| IUPAC Name | N-[1-[(3,4-difluorophenyl)methyl]piperidin-4-yl]-6-(trifluoromethyl)pyridazin-3-amine |
| InChI | InChI=1S/C17H17F5N4/c18-13-2-1-11(9-14(13)19)10-26-7-5-12(6-8-26)23-16-4-3-15(24-25-16)17(20,21)22/h1-4,9,12H,5-8,10H2,(H,23,25) |
| SMILES | C1CN(CCC1NC2=NN=C(C=C2)C(F)(F)F)CC3=CC(=C(C=C3)F)F |
| Reference | X Langlois et al. Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia. J. Pharmacol. Exp. Ther. 2012, 342(1), 91-105.
ET te Beek et al. Pharmacokinetics and central nervous system effects of the novel dopamine D2 receptor antagonist JNJ-37822681. J. Psychopharmacol. 2012, 26(8), 1119-1127. |
