For research use only. Not for therapeutic Use.
Potent negative modulator of AMPA receptor containing TARP-γ8 (Ki value of 26 nM). JNJ 55511118 exhibits excellent pharmacokinetic properties and achieved high receptor occupancy following oral administration. Tool for reversible AMPA receptor inhibition, particularly within the hippocampus, with potential therapeutic utility as an anticonvulsant or neuroprotectant.
KEYWORDS: JNJ 55511118 | supplier | AMPA negative modulator | JNJ-55511118 | JNJ55511118 | CAS [2036081-86-2] | Glutamate | AMPA | Negative modulator | Ion Channels | TARP-γ8 | Neuroprotectant
| Catalog Number | I029838 |
| CAS Number | 2036081-86-2 |
| Molecular Formula | C14H8ClF3N2O2 |
| Purity | ≥95% |
| IUPAC Name | 5-[2-chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydrobenzimidazol-2-one |
| InChI | InChI=1S/C14H8ClF3N2O2/c15-8-2-1-3-11(22-14(16,17)18)12(8)7-4-5-9-10(6-7)20-13(21)19-9/h1-6H,(H2,19,20,21) |
| SMILES | C1=CC(=C(C(=C1)Cl)C2=CC3=C(C=C2)NC(=O)N3)OC(F)(F)F |
| Reference | MP Maher et al. Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8. J Pharmacol Exp Ther. 2016 May;357(2):394-414. |
