JNJ-61432059

• CAT Number: I019399
• CAS Number: 2035814-50-5
• Molecular Formula: C₂₅H₂₂FN₅O₂
• Molecular Weight: 443.47
• Purity: ≥95%
• Target: Neuronal Signaling

JNJ-61432059(CAT: I019399) is a selective negative modulator of AMPA receptors (AMPARs) associated with trans-membrane AMPAR regulatory protein (TARP) γ-8. AMPARs are a type of ion channel receptor found in the central nervous system that plays a crucial role in synaptic transmission and plasticity. JNJ-61432059 specifically targets the AMPAR-TARP γ-8 complex, which is involved in regulating the function of AMPARs. By acting as a negative modulator, JNJ-61432059 reduces the activity of AMPARs, which can have potential therapeutic applications in the treatment of neurological disorders and conditions associated with excessive excitatory signaling.

Reference

[1]. Savall BM, et al. Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators. ACS Med Chem Lett. 2018 Dec 26;10(3):267-272.