JNJ-64619178

• CAT Number: I007454
• CAS Number: 2086772-26-9
• Molecular Formula: C22H23BrN6O2
• Molecular Weight: 483.37
• Purity: ≥95%
• Synonyms: JNJ-64619178; JNJ 64619178; JNJ64619178.;(1S,2R,3S,5R)-3-(2-(2-amino-3-bromoquinolin-7-yl)ethyl)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
• Target: Histone Methyltransferase
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term , or -20°C for long term.
• InChI: InChI=1S/C22H23BrN6O2/c23-15-8-12-3-1-11(7-16(12)28-21(15)25)2-4-13-9-17(19(31)18(13)30)29-6-5-14-20(24)26-10-27-22(14)29/h1,3,5-8,10,13,17-19,30-31H,2,4,9H2,(H2,25,28)(H2,24,26,27)/t13-,17+,18+,19-/m0/s1
• InChIKey: DBSMLQTUDJVICQ-CJODITQLSA-N
• SMILES: O[C@H]1[C@H](N2C=3C(C=C2)=C(N)N=CN3)C[C@H](CCC4=CC5=C(C=C4)C=C(Br)C(N)=N5)[C@H]1O

JNJ-64619178 (CAT: I007454) is indeed a potent and selective PRMT5 (protein arginine methyltransferase 5) inhibitor. PRMT5 is an enzyme involved in the methylation of arginine residues in proteins, and its dysregulation has been implicated in various cancers. By inhibiting PRMT5, JNJ-64619178 disrupts arginine methylation and affects downstream cellular processes involved in tumor growth and progression. Preclinical studies have shown promising antitumor activity of JNJ-64619178, and further research is underway to explore its therapeutic potential in cancer treatment.