For research use only. Not for therapeutic Use.
JNJ-9350 is an inhibitor of spermine oxidase (SMOX) with an IC50 value of 0.01 μM. JNJ-9350 also inhibits polyamine oxidase (PAO) with an IC50 value of 0.79 μM. JNJ-9350 can be used for the research of cancer[1].
JNJ-9350 (0-100 μM) shows inhibitory effect to SMOX, PAO and LSD1 with IC50 values of 10 nM, 790 nM and ＞60 μM, respectively[1].
JNJ-9350 (1.1-70 µM) binds with SMOX with a Ki value of 9.9 nM [1].
1.19
Pharmacokinetic Properties of JNJ-9350 in Mice [1].
MicePO 10 mg/kg
Clearance (mL/min/kg) (Total/Unbound)
73/5217
Volume of distribution (L/kg)
1.7
Half-life (min)
16
PPB (Mouse)
98.6%
Oral F%
34%
| Catalog Number | I042718 |
| CAS Number | 326923-09-5 |
| Synonyms | N-(3-imidazol-1-ylpropyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-2-carboxamide |
| Molecular Formula | C25H22N6O |
| Purity | ≥95% |
| InChI | InChI=1S/C25H22N6O/c32-25(27-12-7-14-30-15-13-26-18-30)22-17-24-28-21(19-8-3-1-4-9-19)16-23(31(24)29-22)20-10-5-2-6-11-20/h1-6,8-11,13,15-18H,7,12,14H2,(H,27,32) |
| InChIKey | RIGHCDSORZCRDE-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C2=CC(=NC3=CC(=NN23)C(=O)NCCCN4C=CN=C4)C5=CC=CC=C5 |
| Reference | [1]. SMOx PROBE PROPOSAL |
