For research use only. Not for therapeutic Use.
(-)-JNJ-A07（Cat No.:I043575）is an investigational compound being developed by Janssen Pharmaceuticals, designed as a selective antagonist of the α7 nicotinic acetylcholine receptor (α7nAChR). This receptor is involved in various neurobiological processes, including cognition, memory, and inflammation. By inhibiting α7nAChR, (-)-JNJ-A07 aims to modulate these pathways and potentially offer therapeutic benefits in conditions like Alzheimer’s disease, schizophrenia, and other cognitive or neuroinflammatory disorders. Preclinical studies are focused on evaluating its safety, efficacy, and potential to improve cognitive function and reduce neuroinflammation, offering a promising approach to CNS-related conditions.
| CAS Number | 2135640-92-3 |
| Molecular Formula | C28H26ClF3N2O6 |
| Purity | ≥95% |
| IUPAC Name | 4-[3-[[1-(4-chlorophenyl)-2-oxo-2-[6-(trifluoromethoxy)-2,3-dihydroindol-1-yl]ethyl]amino]-5-methoxyphenoxy]butanoic acid |
| InChI | InChI=1S/C28H26ClF3N2O6/c1-38-22-13-20(14-23(15-22)39-12-2-3-25(35)36)33-26(18-4-7-19(29)8-5-18)27(37)34-11-10-17-6-9-21(16-24(17)34)40-28(30,31)32/h4-9,13-16,26,33H,2-3,10-12H2,1H3,(H,35,36) |
| InChIKey | WUBVXTOLZKVNEG-UHFFFAOYSA-N |
| SMILES | COC1=CC(=CC(=C1)NC(C2=CC=C(C=C2)Cl)C(=O)N3CCC4=C3C=C(C=C4)OC(F)(F)F)OCCCC(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
