For research use only. Not for therapeutic Use.
JNJ16259685 (Cat.No:I003488) is a selective antagonist of the neuropeptide Y Y2 receptor. It acts as a potent and orally bioavailable small molecule that has been investigated for its potential therapeutic applications in the treatment of obesity, metabolic disorders, and psychiatric disorders. JNJ16259685 exhibits high affinity and selectivity for the Y2 receptor, making it a promising candidate for further research and development.
| Catalog Number | I003488 |
| CAS Number | 409345-29-5 |
| Synonyms | (3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)((1s,4s)-4-methoxycyclohexyl)methanone |
| Molecular Formula | C20H23NO3 |
| Purity | ≥95% |
| Target | GluR |
| Solubility | 10 mM in DMSO |
| Storage | Store at +4C |
| IC50 | 19 nM (mGlu1) |
| IUPAC Name | 3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl-(4-methoxycyclohexyl)methanone |
| InChI | InChI=1S/C20H23NO3/c1-23-17-7-4-13(5-8-17)19(22)14-6-9-18-16(11-14)12-15-3-2-10-24-20(15)21-18/h6,9,11-13,17H,2-5,7-8,10H2,1H3 |
| InChIKey | QOTAQTRFJWLFCR-UHFFFAOYSA-N |
| SMILES | COC1CCC(CC1)C(=O)C2=CC3=CC4=C(N=C3C=C2)OCCC4 |
| Reference | </br>1:Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination. Hodgson RA, Hyde LA, Guthrie DH, Cohen-Williams ME, Leach PT, Kazdoba TM, Bleickardt CJ, Lu SX, Parker EM, Varty GB.Pharmacol Biochem Behav. 2011 Apr;98(2):181-7. doi: 10.1016/j.pbb.2010.11.018. Epub 2010 Nov 28. PMID: 21122808 </br>2:JNJ16259685, a selective mGlu1 antagonist, suppresses isolation-induced aggression in male mice. Navarro JF, De Castro V, Martín-López M.Eur J Pharmacol. 2008 May 31;586(1-3):217-20. doi: 10.1016/j.ejphar.2008.02.070. Epub 2008 Feb 29. PMID: 18367165 </br>3:Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices. Fukunaga I, Yeo CH, Batchelor AM.Br J Pharmacol. 2007 Jul;151(6):870-6. Epub 2007 May 14. PMID: 17502847 Free PMC Article</br>4:JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist. Lavreysen H, Wouters R, Bischoff F, Nóbrega Pereira S, Langlois X, Blokland S, Somers M, Dillen L, Lesage AS.Neuropharmacology. 2004 Dec;47(7):961-72. PMID: 15555631 |
