JNJ4796

• CAT Number: I019305
• CAS Number: 2241664-16-2
• Molecular Formula: C₂₈H₂₇N₉O₃
• Molecular Weight: 537.57
• Purity: ≥95%
• Target: Influenza Virus
• Storage: Store at -20°C
• IUPAC Name: N-[2-[2-[4-[(R)-(2-methyltetrazol-5-yl)-phenylmethyl]piperazine-1-carbonyl]pyridin-4-yl]-1,3-benzoxazol-5-yl]acetamide
• InChI: InChI=1S/C28H27N9O3/c1-18(38)30-21-8-9-24-22(17-21)31-27(40-24)20-10-11-29-23(16-20)28(39)37-14-12-36(13-15-37)25(19-6-4-3-5-7-19)26-32-34-35(2)33-26/h3-11,16-17,25H,12-15H2,1-2H3,(H,30,38)/t25-/m1/s1
• InChIKey: VMAAUIZLAZYALS-RUZDIDTESA-N
• SMILES: CC(=O)NC1=CC2=C(C=C1)OC(=N2)C3=CC(=NC=C3)C(=O)N4CCN(CC4)[C@H](C5=CC=CC=C5)C6=NN(N=N6)C

JNJ4796（Cat No.:I019305）is an orally active small-molecule fusion inhibitor targeting the hemagglutinin (HA) stem region of group 1 influenza A viruses. By binding to this conserved region, it prevents the conformational changes necessary for viral fusion and entry into host cells. Preclinical studies have demonstrated that JNJ4796 effectively neutralizes a broad spectrum of group 1 influenza A viruses and offers protection in mouse models against lethal viral challenges. Its mechanism of action is similar to that of broadly neutralizing antibodies but offers the advantage of oral administration.

Reference

[1]. van Dongen MJP, et al. A small-molecule fusion inhibitor of influenza virus is orally active in mice. Science. 2019 Mar 8;363(6431).