For research use only. Not for therapeutic Use.
JP 1302 dihydrochloride (CAT: I007456) is a compound that acts as an α2C-adrenoceptor antagonist. The α2C-adrenoceptor is a subtype of adrenergic receptor primarily found in the central nervous system. By blocking the activity of this receptor, JP 1302 dihydrochloride interferes with the binding of norepinephrine and other ligands, resulting in altered neurotransmission. The specific antagonism of the α2C-adrenoceptor by JP 1302 dihydrochloride may have potential applications in the treatment of various conditions involving adrenergic signaling dysregulation.
| CAS Number | 1259314-65-2 |
| Synonyms | JP 1302 dihydrochloride; JP1302; JP-1302; JP 1302.;N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride |
| Molecular Formula | C24H26Cl2N4 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| IUPAC Name | N-[4-(4-methylpiperazin-1-yl)phenyl]acridin-9-amine;dihydrochloride |
| InChI | InChI=1S/C24H24N4.2ClH/c1-27-14-16-28(17-15-27)19-12-10-18(11-13-19)25-24-20-6-2-4-8-22(20)26-23-9-5-3-7-21(23)24;;/h2-13H,14-17H2,1H3,(H,25,26);2*1H |
| InChIKey | VVZOADYFJAJZGL-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2=CC=C(C=C2)NC3=C4C=CC=CC4=NC5=CC=CC=C53.Cl.Cl |
| Reference | </br>1:Nakamura M, Suk K, Lee MG, Jang IS. α(2A) adrenoceptor-mediated presynaptic inhibition of GABAergic transmission in rat tuberomammillary nucleus neurons. J Neurochem. 2013 Jun;125(6):832-42. doi: 10.1111/jnc.12259. PubMed PMID: 23570239. |
