JPS014 TFA

• CAT Number: I040832
• Molecular Formula: C48H60F3N7O9S
• Molecular Weight: 968.09
• Purity: ≥95%
• Synonyms: (2S,4R)-1-[(2S)-2-[9-[2-[4-[(2-aminophenyl)carbamoyl]anilino]-2-oxoethoxy]nonanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
• IUPAC Name: (2R,4S)-1-[(2S)-2-[9-[2-[4-[(2-aminophenyl)carbamoyl]anilino]-2-oxoethoxy]nonanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C46H59N7O7S.C2HF3O2/c1-30-41(61-29-49-30)32-18-16-31(17-19-32)26-48-44(58)38-25-35(54)27-53(38)45(59)42(46(2,3)4)52-39(55)15-9-7-5-6-8-12-24-60-28-40(56)50-34-22-20-33(21-23-34)43(57)51-37-14-11-10-13-36(37)47;3-2(4,5)1(6)7/h10-11,13-14,16-23,29,35,38,42,54H,5-9,12,15,24-28,47H2,1-4H3,(H,48,58)(H,50,56)(H,51,57)(H,52,55);(H,6,7)/t35-,38+,42-;/m1./s1
• InChIKey: COZWHQPHRKVWKR-SHHXBDHBSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@H]3C[C@@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCOCC(=O)NC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5N)O.C(=O)(C(F)(F)F)O

JPS014 TFA(CAT: I040832) is a benzamide-based PROTAC (proteolysis targeting chimera) that recruits the Von Hippel-Lindau (VHL) E3 ligase to selectively degrade class I histone deacetylases (HDACs), particularly HDAC1 and HDAC2. By inducing targeted proteasomal degradation, JPS014 TFA offers a powerful approach to modulate epigenetic regulation beyond traditional inhibition. In HCT116 cells, it demonstrates potent HDAC1/2 degradation, resulting in a higher number of differentially expressed genes and enhanced apoptotic activity. The TFA salt form ensures improved stability and solubility for biological assays. JPS014 TFA is a valuable tool for cancer research and the development of next-generation epigenetic therapies.