JR14a

• CAT Number: I029866
• CAS Number: 2411440-41-8
• Molecular Formula: C25H26Cl2N4O3S
• Molecular Weight: 533.468
• Purity: 98%
• Synonyms: JR14a; JR-14a; JR 14a
• Target: Complement System
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-L-arginine
• InChI: InChI=1S/C25H26Cl2N4O3S/c1-14-13-20(21(15-4-8-17(26)9-5-15)16-6-10-18(27)11-7-16)35-22(14)23(32)31-19(24(33)34)3-2-12-30-25(28)29/h4-11,13,19,21H,2-3,12H2,1H3,(H,31,32)(H,33,34)(H4,28,29,30)/t19-/m0/s1
• InChIKey: OHRIKWUZKGNQKQ-IBGZPJMESA-N
• SMILES: N=C(N)NCCC[C@@H](C(O)=O)NC(C1=C(C)C=C(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)S1)=O

JR14a(CAT: I029866), with the chemical name (2E)-3-(3-(2,5-dimethylphenyl)ureido)thiophene-2-carboximidamide, is a novel and potent antagonist of the human Complement C3a receptor. This small molecule selectively targets and blocks the activity of the C3a receptor, a key component of the complement system involved in immune responses and inflammation. The specific inhibition of the C3a receptor by JR14a highlights its potential as a therapeutic agent for conditions related to complement-mediated immune reactions and inflammatory processes.