For research use only. Not for therapeutic Use.
JS230 (Cat No.: I029871) is a potent and selective small-molecule inhibitor used in cancer and immunology research. It targets key signaling pathways involved in tumor growth, immune regulation, and cellular proliferation. With high specificity and bioavailability, JS230 is valuable for studying oncogenic mechanisms, immune checkpoint modulation, and therapeutic interventions. Researchers utilize JS230 to explore potential treatments for cancers such as leukemia, lymphoma, and solid tumors. Its stability and efficacy ensure reliable experimental outcomes, supporting drug discovery and biomedical research in oncology and immunotherapy.
| Synonyms | JS230; JS-230; JS 230; |
| Molecular Formula | C45H45BrFN11O6S |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2-((4-((3-bromophenyl)amino)quinazolin-6-yl)(methyl)amino)ethyl 2-(1-(4-(4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)-4-oxobutyl)-1H-1,2,3-triazol-4-yl)ethane-1-sulfonate |
| InChI | InChI=1S/C45H45BrFN11O6S/c1-55(34-12-14-40-38(27-34)43(49-29-48-40)50-32-7-4-6-31(46)26-32)21-22-64-65(62,63)23-15-33-28-58(54-51-33)16-5-10-42(59)56-17-19-57(20-18-56)45(61)37-24-30(11-13-39(37)47)25-41-35-8-2-3-9-36(35)44(60)53-52-41/h2-4,6-9,11-14,24,26-29H,5,10,15-23,25H2,1H3,(H,53,60)(H,48,49,50) |
| InChIKey | HDBSHKDWWYJNGT-UHFFFAOYSA-N |
| SMILES | BrC1=CC=CC(NC2=NC=NC3=C2C=C(N(C)CCOS(CCC4=CN(CCCC(N5CCN(C(C6=C(F)C=CC(CC(C7=C8C=CC=C7)=NNC8=O)=C6)=O)CC5)=O)N=N4)(=O)=O)C=C3)=C1 |
| Reference | 1: Schmitt J, Huang S, Goodfellow E, Williams C, Jean-Claude BJ. Design and Synthesis of a Trifunctional Molecular System “Programmed” to Block Epidermal Growth Factor Receptor Tyrosine Kinase, Induce High Levels of DNA Damage, and Inhibit the DNA Repair Enzyme (Poly(ADP-ribose) Polymerase) in Prostate Cancer Cells [published online ahead of print, 2020 Jun 2]. J Med Chem. 2020;10.1021/acs.jmedchem.9b02008. doi:10.1021/acs.jmedchem.9b02008 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
