JSH-150

• CAT Number: I019900
• CAS Number: 2247481-21-4
• Molecular Formula: C₂₄H₃₃ClN₆O₂S
• Molecular Weight: 505.08
• Purity: ≥95%
• IUPAC Name: 4-[[[4-[5-chloro-2-[[4-(2-methoxyethylamino)cyclohexyl]amino]pyridin-4-yl]-1,3-thiazol-2-yl]amino]methyl]oxane-4-carbonitrile
• InChI: InChI=1S/C24H33ClN6O2S/c1-32-11-8-27-17-2-4-18(5-3-17)30-22-12-19(20(25)13-28-22)21-14-34-23(31-21)29-16-24(15-26)6-9-33-10-7-24/h12-14,17-18,27H,2-11,16H2,1H3,(H,28,30)(H,29,31)
• InChIKey: XSDZPPRQLIZLDG-UHFFFAOYSA-N
• SMILES: COCCNC1CCC(CC1)NC2=NC=C(C(=C2)C3=CSC(=N3)NCC4(CCOCC4)C#N)Cl

JSH-150（Cat No.:I019900）is a potent and selective inhibitor of the signal transducer and activator of transcription 3 (STAT3), a key protein involved in cell proliferation, survival, and immune response. By inhibiting STAT3 signaling, JSH-150 disrupts tumor growth and induces apoptosis in cancer cells, making it a promising compound in cancer research. STAT3 is frequently overactive in various cancers, and JSH-150’s ability to target this pathway makes it valuable for studying cancer progression and the development of targeted therapies. It is widely used in research exploring new approaches to cancer treatment.

Reference

[1]. Beilei Wang, et al. Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor. Eur J Med Chem. 13 September 2018.