JSH-23

• CAT Number: I004783
• CAS Number: 749886-87-1
• Molecular Formula: C16H20N2
• Molecular Weight: 240.31
• Purity: ≥95%
• Synonyms: 4-methyl-1-N-(3-phenylpropyl)benzene-1,2-diamine
• Target: NF-κB
• Solubility: DMSO: ≥ 56 mg/mL
• Storage: Store at -20 C
• IC50: 7.1 μM
• InChI: InChI=1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
• InChIKey: YMFNPBSZFWXMAD-UHFFFAOYSA-N
• SMILES: CC1=CC=C(NCCCC2=CC=CC=C2)C(N)=C1

JSH-23(CAT: I004783) is a selective inhibitor of the NF-κB signaling pathway, crucial for regulating immune responses, inflammation, and cell survival. It prevents NF-κB translocation into the nucleus, thereby inhibiting the transcription of pro-inflammatory cytokines and other target genes. This compound is widely used in immunology and oncology research to explore the role of NF-κB in inflammation, immune regulation, and cancer progression. JSH-23 is a valuable tool for investigating the therapeutic potential of NF-κB inhibition in inflammatory diseases, autoimmune disorders, and tumor development, supporting drug discovery and the development of targeted therapies.