JTE 607 dihydrochloride

• CAT Number: I011127
• CAS Number: 188791-09-5
• Molecular Formula: C25H33Cl4N3O5
• Molecular Weight: 597.355
• Purity: ≥95%
• Synonyms: N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride
• Target: Interleukin Related
• Solubility: Soluble to 100 mM in water and to 100 mM in DMSO
• Storage: Desiccate at RT
• IUPAC Name: ethyl (2S)-2-[[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]amino]-3-phenylpropanoate;dihydrochloride
• InChI: InChI=1S/C25H31Cl2N3O5.2ClH/c1-3-34-25(33)20(15-17-7-5-4-6-8-17)28-24(32)18-16-19(26)23(21(27)22(18)31)35-14-13-30-11-9-29(2)10-12-30;;/h4-8,16,20,31H,3,9-15H2,1-2H3,(H,28,32);2*1H/t20-;;/m0../s1
• InChIKey: JUJAUEQJEWIWCQ-FJSYBICCSA-N
• SMILES: CCOC(=O)C(CC1=CC=CC=C1)NC(=O)C2=CC(=C(C(=C2O)Cl)OCCN3CCN(CC3)C)Cl.Cl.Cl

JTE 607 dihydrochloride (Cat No.: I011127) is a broad-spectrum cytokine inhibitor that targets pre-mRNA splicing, disrupting inflammatory and oncogenic signaling pathways. It has been studied for its potential in treating inflammatory diseases and cancer by modulating the expression of key cytokines such as TNF-α, IL-6, and IL-1β. JTE 607 is particularly useful in research on RNA processing and immune regulation, making it a valuable tool for understanding cytokine-driven diseases, including autoimmune disorders, sepsis, and malignancies involving aberrant cytokine signaling.