For research use only. Not for therapeutic Use.
Cytokine release inhibitor. Inhibits production of IL-1<span class=/’symbol/’>β</span>, IL-8, IL-6, IL-10 and TNF<span class=/’symbol/’>α</span> (IC<sub>50</sub> values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. Reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model. Induces apoptosis in leukemia cells <em>in vitro</em> and prolongs survival in a mouse leukemia model.
Catalog Number | I011127 |
CAS Number | 188791-09-5 |
Synonyms | N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride |
Molecular Formula | C25H33Cl4N3O5 |
Purity | ≥95% |
Target | Interleukin Related |
Solubility | Soluble to 100 mM in water and to 100 mM in DMSO |
Storage | Desiccate at RT |
IUPAC Name | ethyl (2S)-2-[[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]amino]-3-phenylpropanoate;dihydrochloride |
InChI | InChI=1S/C25H31Cl2N3O5.2ClH/c1-3-34-25(33)20(15-17-7-5-4-6-8-17)28-24(32)18-16-19(26)23(21(27)22(18)31)35-14-13-30-11-9-29(2)10-12-30;;/h4-8,16,20,31H,3,9-15H2,1-2H3,(H,28,32);2*1H/t20-;;/m0../s1 |
InChIKey | JUJAUEQJEWIWCQ-FJSYBICCSA-N |
SMILES | CCOC(=O)C(CC1=CC=CC=C1)NC(=O)C2=CC(=C(C(=C2O)Cl)OCCN3CCN(CC3)C)Cl.Cl.Cl |