For research use only. Not for therapeutic Use.
JTE-907 (Cat.No:I007464) is a drug used in scientific research that acts as a selective CB2 inverse agonist. It has antiinflammatory effects in animal studies,thought to be mediated by an interaction between the CB2 receptor and IgE.
| Catalog Number | I007464 |
| CAS Number | 282089-49-0 |
| Synonyms | JTE-907; JTE 907; JTE907.;N-(1,3-benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-oxo-8-(pentyloxy)-3-Quinolinecarboxamide |
| Molecular Formula | C24H26N2O6 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO |
| Storage | Store at RT |
| IUPAC Name | N-(1,3-benzodioxol-5-ylmethyl)-7-methoxy-2-oxo-8-pentoxy-1H-quinoline-3-carboxamide |
| InChI | InChI=1S/C24H26N2O6/c1-3-4-5-10-30-22-19(29-2)9-7-16-12-17(24(28)26-21(16)22)23(27)25-13-15-6-8-18-20(11-15)32-14-31-18/h6-9,11-12H,3-5,10,13-14H2,1-2H3,(H,25,27)(H,26,28) |
| InChIKey | GRAJFFFXJYFVOC-UHFFFAOYSA-N |
| SMILES | CCCCCOC1=C(C=CC2=C1NC(=O)C(=C2)C(=O)NCC3=CC4=C(C=C3)OCO4)OC |
| Reference | </br>1:Upregulation of the expression of inflammatory and angiogenic markers in human adipocytes by a synthetic cannabinoid, JTE-907. González-Muniesa P, Bing C, Trayhurn P.Horm Metab Res. 2010 Sep;42(10):710-7. doi: 10.1055/s-0030-1255119. Epub 2010 Jul 5. PMID: 20603779 </br>2:The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis. Maekawa T, Nojima H, Kuraishi Y, Aisaka K.Eur J Pharmacol. 2006 Aug 7;542(1-3):179-83. Epub 2006 Jun 2. PMID: 16824511 </br>3:Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice. Ueda Y, Miyagawa N, Matsui T, Kaya T, Iwamura H.Eur J Pharmacol. 2005 Sep 27;520(1-3):164-71. PMID: 16153638 </br>4:In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor. Iwamura H, Suzuki H, Ueda Y, Kaya T, Inaba T.J Pharmacol Exp Ther. 2001 Feb;296(2):420-5. PMID: 11160626 Free Article |
