JTE-952

• CAT Number: I019306
• CAS Number: 1255303-54-8
• Molecular Formula: C30H34N2O6
• Molecular Weight: 518.60
• Purity: ≥95%
• Synonyms: [3-[4-[(4-cyclopropylphenyl)methoxy]-3-methoxyphenyl]azetidin-1-yl]-[4-[[(2S)-2,3-dihydroxypropoxy]methyl]pyridin-2-yl]methanone
• InChI: InChI=1S/C30H34N2O6/c1-36-29-13-24(8-9-28(29)38-18-20-2-4-22(5-3-20)23-6-7-23)25-14-32(15-25)30(35)27-12-21(10-11-31-27)17-37-19-26(34)16-33/h2-5,8-13,23,25-26,33-34H,6-7,14-19H2,1H3/t26-/m0/s1
• InChIKey: LTTJGQBDGMNWHJ-SANMLTNESA-N
• SMILES: COC1=C(C=CC(=C1)C2CN(C2)C(=O)C3=NC=CC(=C3)COC[C@H](CO)O)OCC4=CC=C(C=C4)C5CC5

JTE-952(CAT: I019306) is a selective sphingosine-1-phosphate receptor 2 (S1P2) antagonist, commonly used in advanced pharmaceutical research to explore the role of S1P2 in various physiological and pathological processes. This compound has gained attention for its potential therapeutic applications in treating fibrosis, autoimmune diseases, and certain cardiovascular conditions by modulating the S1P signaling pathway. JTE-952 is characterized by its high specificity and potency, making it an essential tool for researchers investigating S1P-related mechanisms and the development of targeted therapies. Its efficacy in preclinical models underscores its value in drug discovery and development, providing a robust foundation for exploring new therapeutic strategies.