JW 642

For research use only. Not for therapeutic Use.

  • CAT Number: I001596
  • CAS Number: 1416133-89-5
  • Molecular Formula: C21H20F6N2O3
  • Molecular Weight: 462.39
  • Purity: ≥95%
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JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.
IC50 value: 7.6/14/3.7 nM(mouse/rat/human MAGL) [1]
Target: MAGL inhibitor
JW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively).


Catalog Number I001596
CAS Number 1416133-89-5
Synonyms

1,1,1,3,3,3-hexafluoropropan-2-yl 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate

Molecular Formula C21H20F6N2O3
Purity ≥95%
InChI InChI=1S/C21H20F6N2O3/c22-20(23,24)18(21(25,26)27)32-19(30)29-11-9-28(10-12-29)14-15-5-4-8-17(13-15)31-16-6-2-1-3-7-16/h1-8,13,18H,9-12,14H2
InChIKey AVSCNEOUWSVZEY-UHFFFAOYSA-N
SMILES C1CN(CCN1CC2=CC(=CC=C2)OC3=CC=CC=C3)C(=O)OC(C(F)(F)F)C(F)(F)F
Reference

[1]. Chang JW, et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol. 2012 May 25;19(5):579-88.
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