For research use only. Not for therapeutic Use.
JW 55(CAT: I004499) is a potent and selective inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2), key enzymes in the regulation of Wnt/β-catenin signaling. By inhibiting TNKS1/2 activity, JW 55 destabilizes β-catenin, suppressing Wnt-driven transcriptional programs and cellular proliferation. This compound is extensively used in cancer research, particularly in studying Wnt pathway dysregulation and its role in tumorigenesis. Its specificity and effectiveness make JW 55 a valuable tool for investigating TNKS-related pathways and for advancing the development of therapeutic strategies targeting Wnt/β-catenin signaling in oncology.
| Catalog Number | I004499 |
| CAS Number | 664993-53-7 |
| Synonyms | N-[4-[[4-(4-methoxyphenyl)oxan-4-yl]methylcarbamoyl]phenyl]furan-2-carboxamide |
| Molecular Formula | C₂₅H₂₆N₂O₅ |
| Purity | ≥95% |
| Target | Epigenetics |
| Solubility | 10 mM in DMSO |
| Storage | Store at 4°C |
| IC50 | 1.9 uM (TNKS1); 830 nM (TNKS2) [1] |
| IUPAC Name | N-[4-[[4-(4-methoxyphenyl)oxan-4-yl]methylcarbamoyl]phenyl]furan-2-carboxamide |
| InChI | InChI=1S/C25H26N2O5/c1-30-21-10-6-19(7-11-21)25(12-15-31-16-13-25)17-26-23(28)18-4-8-20(9-5-18)27-24(29)22-3-2-14-32-22/h2-11,14H,12-13,15-17H2,1H3,(H,26,28)(H,27,29) |
| InChIKey | ZJZWZIXSGNFWQQ-UHFFFAOYSA-N |
| SMILES | O=C(NC1=CC=C(C(NCC2(C3=CC=C(OC)C=C3)CCOCC2)=O)C=C1)C4=CC=CO4 |
