For research use only. Not for therapeutic Use.
JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM[1]. JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth[1].
JW67 (1 μM; 24 hours) increases concentration of AXIN2 and decreases the active form of β-catenin[1].
JW67 affects the expression of Wnt target genes and reduces cell growth of colon cancer cell lines[1].
JW67 shows a concentrationdependent reduction in proliferation with a GI50 value of 7.8 μM[1].
| Catalog Number | I010998 |
| CAS Number | 442644-28-2 |
| Molecular Formula | C21H18N2O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H18N2O6/c24-17-20(13-5-1-3-7-15(13)22-17)26-9-19(10-27-20)11-28-21(29-12-19)14-6-2-4-8-16(14)23-18(21)25/h1-8H,9-12H2,(H,22,24)(H,23,25) |
| InChIKey | BTXRSHKJNDFHGA-UHFFFAOYSA-N |
| SMILES | C1C2(COC3(O1)C4=CC=CC=C4NC3=O)COC5(C6=CC=CC=C6NC5=O)OC2 |
| Reference | [1]. Waaler J, et al. Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res. 2011;71(1):197-205. |
