For research use only. Not for therapeutic Use.
JWH 018 (1-<wbr></wbr>pentyl-<wbr></wbr>3-<wbr></wbr>(1-<wbr></wbr>naphthoyl)indole) is a synthetic cannabinoid (CB) that potently activates the central CB<sub>1</sub> and peripheral CB<sub>2</sub> receptors (K<sub>i</sub> = 9.0 and 2.94 nM, respectively). This cannabimimetic compound has frequently been found in herbal blends. JWH 018 2’-<wbr></wbr>naphthyl-<wbr></wbr>N-<wbr></wbr>(1-<wbr></wbr>methylbutyl) isomer differs structurally from JWH 018 by having the naphthyl group attached at the 2’ position and 1-<wbr></wbr>methylbutyl in place of the pentyl chain. The biological activities of this compound have not been characterized.
| Catalog Number | R067465 |
| Synonyms | naphthalen-2-yl(1-(pentan-2-yl)-1H-indol-3-yl)methanone |
| Molecular Formula | C24H23NO |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C24H23NO/c1-3-8-17(2)25-16-22(21-11-6-7-12-23(21)25)24(26)20-14-13-18-9-4-5-10-19(18)15-20/h4-7,9-17H,3,8H2,1-2H3 |
| InChIKey | KTHPRMCSIRQVGE-UHFFFAOYSA-N |
| SMILES | O=C(C1=CC=C(C=CC=C2)C2=C1)C3=CN(C(C)CCC)C4=CC=CC=C43 |
| Reference | 1.Aung, M.M.,Griffin, G.,Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence 60, 133-140 (2000). |
