For research use only. Not for therapeutic Use.
JWH 018 is a mildly selective agonist of the peripheral cannabinoid (CB<sub>2</sub>) receptor, derived from the aminoalkylindole WIN 55,212-<wbr></wbr>2. The K<sub>i</sub> values for binding central cannabinoid (CB<sub>1</sub>) and CB<sub>2</sub> receptors are 9.0 and 2.94 nM, respectively, for a CB<sub>1</sub>:CB<sub>2</sub> ratio of 3.06. JWH 018 is one of several synthetic CBs which have been included in smoking mixtures. JWH 018 N-<wbr></wbr>(5-<wbr></wbr>hydroxypentyl) metabolite is a major urinary metabolite of JWH 018, characterized by monohydroxylation of the N-<wbr></wbr>alkyl chain. In urine samples, this metabolite is almost completely glucuronidated.
| Catalog Number | R067341 |
| CAS Number | 335161-21-2 |
| Synonyms | (1-(5-hydroxypentyl)-1H-indol-3-yl)(naphthalen-1-yl)-methanone |
| Molecular Formula | C24H23NO2 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | [1-(5-hydroxypentyl)indol-3-yl]-naphthalen-1-ylmethanone |
| InChI | InChI=1S/C24H23NO2/c26-16-7-1-6-15-25-17-22(20-12-4-5-14-23(20)25)24(27)21-13-8-10-18-9-2-3-11-19(18)21/h2-5,8-14,17,26H,1,6-7,15-16H2 |
| InChIKey | UGHBAICDASCCIQ-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C=CC=C2C(=O)C3=CN(C4=CC=CC=C43)CCCCCO |
