For research use only. Not for therapeutic Use.
JWH 073 is a mildly selective agonist of the central cannabinoid (CB<sub>1</sub>) receptor derived from the aminoalkylindole WIN 55,212-<wbr></wbr>2. The K<sub>i</sub> values for binding CB<sub>1</sub> and the peripheral cannabinoid (CB<sub>2</sub>) receptor are 8.9 and 38 nM, respectively for a CB<sub>1</sub>:CB<sub>2</sub> ratio of 0.23. Its effects on suppression of spontaneous activity, maximum possible antinociceptive effect in the tail-<wbr></wbr>flick assay, and rectal temperature are comparable to those of WIN 55,212-<wbr></wbr>2 when tested in rats.
| Catalog Number | R051076 |
| CAS Number | 208987-48-8 |
| Synonyms | (1-butyl-1H-indol-3-yl)-1-naphthalenyl-methanone |
| Molecular Formula | C23H21NO |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C23H21NO/c1-2-3-15-24-16-21(19-12-6-7-14-22(19)24)23(25)20-13-8-10-17-9-4-5-11-18(17)20/h4-14,16H,2-3,15H2,1H3 |
| InChIKey | VCHHHSMPMLNVGS-UHFFFAOYSA-N |
| SMILES | CCCCn1cc(C(=O)c2cccc3ccccc23)c2ccccc12 |
| Reference | 1.Aung, M.M.,Griffin, G.,Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence 60, 133-140 (2000). |
