For research use only. Not for therapeutic Use.
JWH 081 (Item No. <span class=/itemid/>10579</span>) is a cannabimimetic indole related to JWH 015 (Item No. <span class=/itemid/>10009018</span>) and JWH 018 (Item No. <span class=/itemid/>10900</span>) that shows preference for the central cannabinoid (CB<sub>1</sub>) receptor (K<sub>i</sub> = 1.2 nM) over the peripheral cannabinoid (CB<sub>2</sub>) receptor (K<sub>i</sub> = 12.4 nM). JWH 081 4-<wbr></wbr>hydroxynaphthyl metabolite is an expected metabolite of JWH 081 that would be detectable both in serum and in urine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic purposes.
| Catalog Number | R064771 |
| CAS Number | 1393345-76-0 |
| Synonyms | (4-hydroxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-methanone |
| Molecular Formula | C24H23NO2 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | (4-hydroxynaphthalen-1-yl)-(1-pentylindol-3-yl)methanone |
| InChI | InChI=1S/C24H23NO2/c1-2-3-8-15-25-16-21(18-10-6-7-12-22(18)25)24(27)20-13-14-23(26)19-11-5-4-9-17(19)20/h4-7,9-14,16,26H,2-3,8,15H2,1H3 |
| InChIKey | SVZBBFXTYNKESE-UHFFFAOYSA-N |
| SMILES | CCCCCN1C=C(C2=CC=CC=C21)C(=O)C3=CC=C(C4=CC=CC=C43)O |
| Reference | 1.Aung, M.M.,Griffin, G.,Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence 60, 133-140 (2000). |
