For research use only. Not for therapeutic Use.
JWH 081 is a synthetic cannabinoid (CB) that shows a high-<wbr></wbr>affinity for the central CB<sub>1</sub> receptor with a K<sub>i</sub> value of 1.2 nM and ten-<wbr></wbr>fold reduced affinity for the peripheral CB<sub>2</sub> receptor (K<sub>i</sub> = 12.4 nM). JWH 081 8-<wbr></wbr>methoxynaphthyl isomer differs structurally from JWH 081 by having the methoxy group attached to the naphthyl rings at the 8 position, instead of the 4 position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.
| Catalog Number | R067496 |
| CAS Number | 1349837-48-4 |
| Synonyms | (8-methoxynaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone |
| Molecular Formula | C25H25NO2 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | (8-methoxynaphthalen-1-yl)-(1-pentylindol-3-yl)methanone |
| InChI | InChI=1S/C25H25NO2/c1-3-4-7-16-26-17-21(19-12-5-6-14-22(19)26)25(27)20-13-8-10-18-11-9-15-23(28-2)24(18)20/h5-6,8-15,17H,3-4,7,16H2,1-2H3 |
| InChIKey | CNQSHGRPSVJODG-UHFFFAOYSA-N |
| SMILES | CCCCCN1C=C(C2=CC=CC=C21)C(=O)C3=CC=CC4=C3C(=CC=C4)OC |
| Reference | 1.Aung, M.M.,Griffin, G.,Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence 60, 133-140 (2000). |
