For research use only. Not for therapeutic Use.
JWH 203 is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid (CB) agonist with K<sub>i</sub> values of 8.0 and 7.0 nM at the central (CB<sub>1</sub>) and peripheral (CB<sub>2</sub>) receptors, respectively. Similar to the related 2/’-<wbr></wbr>methoxy compound JWH 250 (Item No. <span class=/itemid/>13634</span>), JWH 203 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole CB compounds. Compared to JWH 250, JWH 203 displays slightly more potent binding affinities for the CB<sub>1</sub> and CB<sub>2</sub> CB receptors (JWH 250 K<sub>i</sub>s = 11 and 33 nM, respectively). JWH 203 N-<wbr></wbr>(5-<wbr></wbr>hydroxypentyl) metabolite is expected to be a metabolite of JWH 203 that would be detectable both in serum and in urine.
| Catalog Number | R064725 |
| CAS Number | 1843184-37-1 |
| Synonyms | 2-(2-chlorophenyl)-1-(1-(5-hydroxypentyl)-1H-indol-3-yl)ethan-1-one |
| Molecular Formula | C21H22ClNO2 |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C21H22ClNO2/c22-19-10-4-2-8-16(19)14-21(25)18-15-23(12-6-1-7-13-24)20-11-5-3-9-17(18)20/h2-5,8-11,15,24H,1,6-7,12-14H2 |
| InChIKey | RFHPYWJZEUWQOM-UHFFFAOYSA-N |
| SMILES | O=C(CC1=C(Cl)C=CC=C1)C2=CN(CCCCCO)C3=CC=CC=C32 |
| Reference | 1.Huffman, J.W.,Szklennik, P.V.,Almond, A., et al. 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorganic & Medicinal Chemistry Letters 15, 4110-4113 (2005). |
