For research use only. Not for therapeutic Use.
JX-06（Cat No.:I007467）is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis. By inhibiting NAMPT, JX-06 depletes cellular NAD+ levels, disrupting critical processes such as energy metabolism and DNA repair, particularly in rapidly proliferating cancer cells. This inhibition leads to cancer cell apoptosis, making JX-06 a promising candidate for anticancer therapy. Preclinical studies have shown its effectiveness in reducing tumor growth, particularly in cancers that rely heavily on NAD+ metabolism. JX-06 represents a targeted therapeutic approach in cancer treatment by modulating cellular metabolism.
| Catalog Number | I007467 |
| CAS Number | 729-46-4 |
| Synonyms | JX-06; JX 06; JX06.;Bis(morpholinothiocarbonyl) disulfide |
| Molecular Formula | C10H16N2O2S4 |
| Purity | ≥95% |
| Target | Apoptosis |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| IC50 | 28nM |
| IUPAC Name | morpholine-4-carbothioylsulfanyl morpholine-4-carbodithioate |
| InChI | InChI=1S/C10H16N2O2S4/c15-9(11-1-5-13-6-2-11)17-18-10(16)12-3-7-14-8-4-12/h1-8H2 |
| InChIKey | KKVYOWPPMNSLCP-UHFFFAOYSA-N |
| SMILES | C1COCCN1C(=S)SSC(=S)N2CCOCC2 |
| Reference | </br>1:Sun W, Xie Z, Liu Y, Zhao D, Wu Z, Zhang D, Lv H, Tang S, Jin N, Jiang H, Tan M, Ding J, Luo C, Li J, Huang M, Geng M. JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification. Cancer Res. 2015 Nov 15;75(22):4923-36. doi: 10.1158/0008-5472.CAN-15-1023. PubMed PMID: 26483203. |
