JYL-79

• CAT Number: I029927
• CAS Number: 289902-64-3
• Molecular Formula: C26H36N2O4S
• Molecular Weight: 472.64
• Purity: 98%
• Synonyms: JYL-79; JYL 79; JYL79
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2,2-Dimethyl-propanoic acid 3-(3,4-dimethylphenyl)-2-[[[[[(4-hydroxy-3-methoxyphenyl)methyl]amino]thioxomethyl]amino]methyl]propyl ester
• InChI: InChI=1S/C26H36N2O4S/c1-17-7-8-19(11-18(17)2)12-21(16-32-24(30)26(3,4)5)15-28-25(33)27-14-20-9-10-22(29)23(13-20)31-6/h7-11,13,21,29H,12,14-16H2,1-6H3,(H2,27,28,33)
• InChIKey: KDYVIORLSJSMTG-UHFFFAOYSA-N
• SMILES: CC(C)(C)C(OCC(CNC(NCC1=CC=C(O)C(OC)=C1)=S)CC2=CC=C(C)C(C)=C2)=O

JYL-79(CAT: I029927) is a potent and selective vanilloid receptor 1 (VR1) agonist, also known as the transient receptor potential vanilloid 1 (TRPV1) receptor. TRPV1 is a non-selective cation channel primarily involved in the detection and regulation of pain, heat, and inflammatory stimuli. By activating TRPV1, JYL-79 induces calcium influx in sensory neurons, mimicking the effects of capsaicin and contributing to pain signaling and thermal sensation. JYL-79 is widely used in pain research to study nociceptive pathways and explore potential therapies for conditions like chronic pain, neuropathic pain, and inflammatory disorders.