For research use only. Not for therapeutic Use.
JZL195（Cat No.:I000785）is a dual inhibitor of the endocannabinoid-degrading enzymes monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH). By inhibiting both enzymes, JZL195 elevates levels of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide, enhancing cannabinoid receptor signaling. This mechanism offers potential therapeutic effects in managing pain, inflammation, anxiety, and neurodegenerative diseases. JZL195 is frequently utilized in preclinical research to investigate the physiological roles of endocannabinoids and the potential for targeting the endocannabinoid system to treat various disorders, promoting a balanced approach in cannabinoid-based therapy research.
| Catalog Number | I000785 |
| CAS Number | 1210004-12-8 |
| Synonyms | 4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate |
| Molecular Formula | C₂₄H₂₃N₃O₅ |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | DMSO: ≥ 42 mg/mL |
| Storage | Store at -20C |
| IC50 | 13 nM/19 nM (mouse brain FAAH/MAGL) |
| IUPAC Name | (4-nitrophenyl) 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate |
| InChI | InChI=1S/C24H23N3O5/c28-24(32-22-11-9-20(10-12-22)27(29)30)26-15-13-25(14-16-26)18-19-5-4-8-23(17-19)31-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2 |
| InChIKey | QNYRAEKLMNDRFY-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1CC2=CC(=CC=C2)OC3=CC=CC=C3)C(=O)OC4=CC=C(C=C4)[N+](=O)[O-] |
| Reference | </br>1:Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model. Adamson Barnes NS, Mitchell VA, Kazantzis NP, Vaughan CW.Br J Pharmacol. 2016 Jan;173(1):77-87. doi: 10.1111/bph.13337. Epub 2015 Dec 1. PMID: 26398331 Free PMC Article</br>2:The dual FAAH/MAGL inhibitor JZL195 has enhanced effects on endocannabinoid transmission and motor behavior in rats as compared to those of the MAGL inhibitor JZL184. Seillier A, Dominguez Aguilar D, Giuffrida A.Pharmacol Biochem Behav. 2014 Sep;124:153-9. doi: 10.1016/j.pbb.2014.05.022. Epub 2014 Jun 6. PMID: 24911644 Free PMC Article</br>3:Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model. Anderson WB, Gould MJ, Torres RD, Mitchell VA, Vaughan CW.Neuropharmacology. 2014 Jun;81:224-30. doi: 10.1016/j.neuropharm.2013.12.018. Epub 2013 Dec 30. PMID: 24384256 |
