JZP-110 hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I009552
  • CAS Number: 178429-65-7
  • Molecular Formula: C10H15ClN2O2
  • Molecular Weight: 230.692
  • Purity: ≥95%
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JZP-110 hydrochloride (CAT: I009552) is a wake-promoting agent and stimulant used for the treatment of excessive daytime sleepiness associated with narcolepsy, obstructive sleep apnea, and shift work disorder. It is a selective dopamine and norepinephrine reuptake inhibitor (DNRI) that increases the levels of these neurotransmitters in the brain, promoting wakefulness and reducing sleepiness. JZP-110 hydrochloride has shown efficacy in improving wakefulness and reducing sleep attacks in clinical studies. It is a promising option for individuals with sleep disorders who require increased wakefulness and improved daytime functioning.


Catalog Number I009552
CAS Number 178429-65-7
Synonyms

R228060; R-228060; R 228060; JZP-110; ADX-N-05; ARL-N-05; R-228060; SKL-N-05; YKP-10A; ADXN-05; ARLN-05; SKLN-05; Solriamfetol. Solriamfetol hydrochloride.;(R)-2-amino-3-phenylpropyl carbamate hydrochloride

Molecular Formula C10H15ClN2O2
Purity ≥95%
Solubility Soluble in DMSO
Storage 0 - 4 °C for short term, or -20 °C for long term
Related CAS 178429-62-4 (free base)    
IUPAC Name [(2R)-2-amino-3-phenylpropyl] carbamate;hydrochloride
InChI InChI=1S/C10H14N2O2.ClH/c11-9(7-14-10(12)13)6-8-4-2-1-3-5-8;/h1-5,9H,6-7,11H2,(H2,12,13);1H/t9-;/m1./s1
InChIKey KAOVAAHCFNYXNJ-SBSPUUFOSA-N
SMILES C1=CC=C(C=C1)CC(COC(=O)N)N.Cl
Reference

<p>
<span style=”color:#000000;”><span style=”font-size:12px;”><span style=”font-family:arial,helvetica,sans-serif;”>1. Scrima L, Emsellem HA, Becker PM, Ruoff C, Lankford A, Bream G, Khayrallah M, Lu Y, Black J. Identifying clinically important difference on the Epworth Sleepiness Scale: results from a narcolepsy clinical trial of JZP-110. Sleep Med. 2017 Oct;38:108-112. doi: 10.1016/j.sleep.2017.07.006. Epub 2017 Jul 22. PubMed PMID: 29031743.<br />
2. Ruoff C, Bogan RK, Emsellem H, Feldman N, Lankford A, Bream G, Khayrallah M, Lu Y, Carter LP, Black J. Evaluation of the effect of JZP-110 in patients with narcolepsy assessed using the Maintenance of Wakefulness Test censored to 20 minutes. Sleep Med. 2017 Jul;35:12-16. doi: 10.1016/j.sleep.2017.03.025. Epub 2017 Apr 22. PubMed PMID: 28619176.<br />
3. Ruoff C, Swick TJ, Doekel R, Emsellem HA, Feldman NT, Rosenberg R, Bream G, Khayrallah MA, Lu Y, Black J. Effect of Oral JZP-110 (ADX-N05) on Wakefulness and Sleepiness in Adults with Narcolepsy: A Phase 2b Study. Sleep. 2016 Jul 1;39(7):1379-87. doi: 10.5665/sleep.5968. PubMed PMID: 27166238; PubMed Central PMCID: PMC4909620.<br />
4. Bogan RK, Feldman N, Emsellem HA, Rosenberg R, Lu Y, Bream G, Khayrallah M, Lankford DA. Effect of oral JZP-110 (ADX-N05) treatment on wakefulness and sleepiness in adults with narcolepsy. Sleep Med. 2015 Sep;16(9):1102-8. doi: 10.1016/j.sleep.2015.05.013. Epub 2015 Jun 3. PubMed PMID: 26298786.</span></span></span></p>

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