K 114

• CAT Number: I010709
• CAS Number: 872201-12-2
• Molecular Formula: C22H17BrO2
• Molecular Weight: 393.28
• Purity: ≥95%
• Synonyms: 4,4/’-[(2-Bromo-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol
• Target: Fluorescent Probes
• Solubility: Soluble to 100 mM in DMSO and to 50 mM in ethanol
• Storage: Store at +4C
• IUPAC Name: 4-[(E)-2-[3-bromo-4-[(E)-2-(4-hydroxyphenyl)ethenyl]phenyl]ethenyl]phenol
• InChI: InChI=1S/C22H17BrO2/c23-22-15-18(2-1-16-5-11-20(24)12-6-16)4-10-19(22)9-3-17-7-13-21(25)14-8-17/h1-15,24-25H/b2-1+,9-3+
• InChIKey: OXPHQQMZTXMEGO-RJTULKDBSA-N
• SMILES: C1=CC(=CC=C1C=CC2=CC(=C(C=C2)C=CC3=CC=C(C=C3)O)Br)O

K 114(CAT: I010709) is a potent amyloid fibril-specific fluorescent dye with an EC₅₀ of 20–30 nM, widely utilized in neurodegenerative disease and protein aggregation research. It exhibits minimal fluorescence in aqueous buffers but fluoresces brightly upon binding to amyloid fibrils, including Aβ, α-synuclein, and tau, making it ideal for detecting pathological protein aggregates. K 114 is optimized for use at a wavelength of 550 nm, providing high sensitivity and specificity for studying amyloid fibril formation and localization in situ. Its utility in visualizing amyloid deposits makes it a valuable tool for advancing research into Alzheimer’s disease, Parkinson’s disease, and other amyloid-related conditions.