K-115 free base

• CAT Number: I002718
• CAS Number: 223645-67-8
• Molecular Formula: C15H18FN3O2S
• Molecular Weight: 323.39
• Purity: ≥95%
• Target: ROCK inhibitor
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 31 nM [1]

K-115 free base(CAT: I002718), also known as K-115 hydrochloride, is a highly selective and potent inhibitor of Rho-kinase. It belongs to the class of isoquinolinesulfonamide compounds and has an IC50 value of 31 nM, indicating its strong inhibitory activity against Rho-kinase. Rho-kinase is an enzyme involved in the regulation of various cellular processes, including smooth muscle contraction, cell motility, and cytoskeletal organization. By inhibiting Rho-kinase, K-115 free base has the potential to modulate these processes, making it a valuable tool in research and potentially for therapeutic applications.

Reference

[1]. Patent EP 2628482 A1: Rho kinase inhiitors for use in the treatment of neuroblastoma
[2]. Tanihara H, et al. Phase 1 clinical trials of a selective Rho kinase inhibitor, K-115. JAMA Ophthalmol. 2013 Oct;131(10):1288-95.
[3]. Isobe T, et al. Effects of K-115, a rho-kinase inhibitor, on aqueous humor dynamics in rabbits. Curr Eye Res. 2014 Aug;39(8):813-22.
[4]. Yamamoto K, et al. The novel Rho kinase (ROCK) inhibitor K-115: a new candidate drug for neuroprotective treatment in glaucoma. Invest Ophthalmol Vis Sci. 2014 Oct 2. pii: IOVS-13-13842.