K-11777

• CAT Number: I007471
• CAS Number: 233277-99-1
• Molecular Formula: C32H38N4O4S
• Molecular Weight: 574.74
• Purity: ≥95%
• Synonyms: APC-3316; APC3316; APC 3316; K-11777; K 11777; K11777; K 777; K-777; K777; CRA-3316; CRA3316; CRA 3316.;4-methyl-N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)piperazine-1-carboxamide
• Target: Immunology/Inflammation
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term , or -20°C for long term.
• IC50: 57 nmol/l
• IUPAC Name: N-[(2S)-1-[[(E,3S)-1-(benzenesulfonyl)-5-phenylpent-1-en-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]-4-methylpiperazine-1-carboxamide
• InChI: InChI=1S/C32H38N4O4S/c1-35-20-22-36(23-21-35)32(38)34-30(25-27-13-7-3-8-14-27)31(37)33-28(18-17-26-11-5-2-6-12-26)19-24-41(39,40)29-15-9-4-10-16-29/h2-16,19,24,28,30H,17-18,20-23,25H2,1H3,(H,33,37)(H,34,38)/b24-19+/t28-,30-/m0/s1
• InChIKey: RHJLQMVZXQKJKB-FPHSVDBKSA-N
• SMILES: CN1CCN(CC1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCC3=CC=CC=C3)C=CS(=O)(=O)C4=CC=CC=C4

K-11777 is a potent and selective inhibitor of cysteine proteases, particularly targeting the enzyme cruzipain, which plays a crucial role in the life cycle of Trypanosoma cruzi, the causative agent of Chagas disease. By inhibiting cruzipain, K-11777 disrupts parasite replication and survival, making it a promising candidate for antiparasitic drug development. Its efficacy has been explored in various models of Chagas disease, where it has shown potential in reducing parasite burden and disease progression. K-11777 is valuable in research focused on developing therapies for neglected tropical diseases like Chagas.