For research use only. Not for therapeutic Use.
K-604 dihydrochloride（Cat No.:I012962）is a synthetic compound being studied for its potential therapeutic applications, particularly in the treatment of neurological disorders. It is part of a class of molecules that may act on specific neurotransmitter systems to modulate brain activity. Research on K-604 dihydrochloride is still in the early stages, and its exact mechanism of action, as well as its efficacy and safety profile, are yet to be fully understood. Studies are ongoing to explore its potential in treating conditions like depression, anxiety, or neurodegenerative diseases, although results have not been conclusive.
| Catalog Number | I012962 |
| CAS Number | 217094-32-1 |
| Molecular Formula | C₂₃H₃₂Cl₂N₆OS₃ |
| Purity | ≥95% |
| Target | Acyltransferase |
| Solubility | DMSO |
| IUPAC Name | 2-[4-[2-(1H-benzimidazol-2-ylsulfanyl)ethyl]piperazin-1-yl]-N-[6-methyl-2,4-bis(methylsulfanyl)pyridin-3-yl]acetamide;dihydrochloride |
| InChI | InChI=1S/C23H30N6OS3.2ClH/c1-16-14-19(31-2)21(22(24-16)32-3)27-20(30)15-29-10-8-28(9-11-29)12-13-33-23-25-17-6-4-5-7-18(17)26-23;;/h4-7,14H,8-13,15H2,1-3H3,(H,25,26)(H,27,30);2*1H |
| InChIKey | DEKWEGUBUYKTAV-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C(=N1)SC)NC(=O)CN2CCN(CC2)CCSC3=NC4=CC=CC=C4N3)SC.Cl.Cl |
| Reference | [1]. Ikenoya M, et al. A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels. Atherosclerosis. 2007 Apr;191(2):290-7.<br>[2]. Shibuya Y, et al. Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer//’s disease mouse and reduces human P301L-tau content at the presymptomatic stage. Neurobiol Aging. 2015 Jul;36(7):2248-2259. |
