For research use only. Not for therapeutic Use.
Building block for synthesis of dihydropyrazolopyrimidine inhibitors of Kv1.5 (IKur). The ethylester analog of inhibitor 1734 is a modest inhibitor itself (IC50 value 1.1 µM for human Kv1.5), but exhibiting encouraging KV1.5 versus L-type calcium channel selectivity.
KEYWORDS: K+ Channel inhibitor 1734 | supplier | Building block | CAS [343240-54-0] | [1026960-80-4] | Potassium | Kv1.5 | Ikur | BMS | L-type | calcium channel
| Catalog Number | I047559 |
| CAS Number | 343240-54-0 |
| Molecular Formula | C15H13Cl2N3O2 |
| Purity | ≥95% |
| IUPAC Name | methyl 7-(2,3-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate |
| InChI | InChI=1S/C15H13Cl2N3O2/c1-8-12(15(21)22-2)14(20-11(19-8)6-7-18-20)9-4-3-5-10(16)13(9)17/h3-7,14,19H,1-2H3 |
| SMILES | CC1=C(C(N2C(=CC=N2)N1)C3=C(C(=CC=C3)Cl)Cl)C(=O)OC |
| Reference | HJ Finlay et al. Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1743-7.
KS Atwal et al. Preparation of pyrazolo[1,5-a]pyrimidines as potassium channel inhibitors. PCT Int. Appl. (2001), WO 2001040231 A1 20010607 |
