K-Ras G12C-IN-1

• CAT Number: I002111
• CAS Number: 1629265-17-3
• Molecular Formula: C22H23Cl2N3O3
• Molecular Weight: 448.34
• Purity: ≥95%
• Synonyms: 1-[4-[2-[4-chloro-5-(2-chlorophenyl)-2-methoxyanilino]acetyl]piperazin-1-yl]prop-2-en-1-one
• InChI: InChI=1S/C22H23Cl2N3O3/c1-3-21(28)26-8-10-27(11-9-26)22(29)14-25-19-12-16(18(24)13-20(19)30-2)15-6-4-5-7-17(15)23/h3-7,12-13,25H,1,8-11,14H2,2H3
• InChIKey: ZJWLFLPGQCYBSE-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C(=C1)Cl)C2=CC=CC=C2Cl)NCC(=O)N3CCN(CC3)C(=O)C=C

K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C extracted from patent WO 2014152588 A1.
IC50 value:
Target: K-ras G12C inhibitor