For research use only. Not for therapeutic Use.
K-Ras(G12C) inhibitor 12(Cat No.:I001782)is an allosteric inhibitor specifically designed to target the oncogenic K-Ras(G12C) mutant. It belongs to a class of small molecules that irreversibly bind to the common tumorigenic mutant K-Ras(G12C) and disrupt its interaction. These inhibitors have shown the ability to decrease activity and increase apoptosis in cancer cell lines containing the G12C mutation. K-Ras(G12C) inhibitor 12 represents a promising therapeutic approach to target K-Ras(G12C) mutant-driven cancers and potentially provide new treatment options for patients with these types of malignancies.
Catalog Number | I001782 |
CAS Number | 1469337-95-8 |
Synonyms | 1-[4-[2-(4-chloro-2-hydroxy-5-iodoanilino)acetyl]piperazin-1-yl]prop-2-en-1-one |
Molecular Formula | C15H17ClIN3O3 |
Purity | ≥95% |
Target | MAPK/ERK Pathway |
Solubility | DMSO: ≥ 48 mg/mL |
Storage | Store at -20°C |
IC50 | 0.32 μM (EC50) |
IUPAC Name | 1-[4-[2-(4-chloro-2-hydroxy-5-iodoanilino)acetyl]piperazin-1-yl]prop-2-en-1-one |
InChI | InChI=1S/C15H17ClIN3O3/c1-2-14(22)19-3-5-20(6-4-19)15(23)9-18-12-8-11(17)10(16)7-13(12)21/h2,7-8,18,21H,1,3-6,9H2 |
InChIKey | JFIFBWVNHLXJFY-UHFFFAOYSA-N |
SMILES | C=CC(=O)N1CCN(CC1)C(=O)CNC2=CC(=C(C=C2O)Cl)I |
Reference | <p style=/line-height:25px/> |