K-Ras(G12C) inhibitor 12

• CAT Number: I001782
• CAS Number: 1469337-95-8
• Molecular Formula: C15H17ClIN3O3
• Molecular Weight: 449.67
• Purity: ≥95%
• Synonyms: 1-[4-[2-(4-chloro-2-hydroxy-5-iodoanilino)acetyl]piperazin-1-yl]prop-2-en-1-one
• Target: Ras
• Solubility: DMSO: ≥ 48 mg/mL
• Storage: Store at -20°C
• IC50: 0.32 μM (EC50)
• InChI: InChI=1S/C15H17ClIN3O3/c1-2-14(22)19-3-5-20(6-4-19)15(23)9-18-12-8-11(17)10(16)7-13(12)21/h2,7-8,18,21H,1,3-6,9H2
• InChIKey: JFIFBWVNHLXJFY-UHFFFAOYSA-N
• SMILES: C=CC(=O)N1CCN(CC1)C(=O)CNC2=CC(=C(C=C2O)Cl)I

K-Ras(G12C) inhibitor 12（Cat No.:I001782）is an allosteric inhibitor specifically designed to target the oncogenic K-Ras(G12C) mutant. It belongs to a class of small molecules that irreversibly bind to the common tumorigenic mutant K-Ras(G12C) and disrupt its interaction. These inhibitors have shown the ability to decrease activity and increase apoptosis in cancer cell lines containing the G12C mutation. K-Ras(G12C) inhibitor 12 represents a promising therapeutic approach to target K-Ras(G12C) mutant-driven cancers and potentially provide new treatment options for patients with these types of malignancies.

Reference

[1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-551.