k-Strophanthidin

• CAT Number: R063406
• CAS Number: 66-28-4
• Molecular Formula: C23H32O6
• Molecular Weight: 404.503
• Purity: ≥95%
• Synonyms: (3β,5β)-3,5,14-Trihydroxy-19-oxo-card-20(22)-enolide;?3β,5,14-Trihydroxy-19-oxo-5β-card-20(22)-enolide; Apocymarin; Convallatoxigenin; Corchorin; Corchoside A aglycon; Corchsularin; Erysimupicrone; Erysimupikron; NSC 86078; Strophanthidin K; Strophan
• Target: Na+/K+ ATPase
• Storage: -20°C
• IUPAC Name: (3S,5S,8R,9S,10S,13R,14S,17R)-3,5,14-trihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde
• InChI: InChI=1S/C23H32O6/c1-20-6-3-17-18(4-8-22(27)11-15(25)2-7-21(17,22)13-24)23(20,28)9-5-16(20)14-10-19(26)29-12-14/h10,13,15-18,25,27-28H,2-9,11-12H2,1H3/t15-,16+,17-,18+,20+,21-,22-,23-/m0/s1
• InChIKey: ODJLBQGVINUMMR-HZXDTFASSA-N
• SMILES: CC12CCC3C(C1(CCC2C4=CC(=O)OC4)O)CCC5(C3(CCC(C5)O)C=O)O

K-strophanthidin is a cardiac glycoside compound derived from plants of the Strophanthus genus, known for its medicinal properties. This molecule acts on the heart by inhibiting the sodium-potassium ATPase pump, leading to increased contractility and cardiac output. Historically, k-strophanthidin was used to treat heart conditions like congestive heart failure and arrhythmias. However, due to its narrow therapeutic window and potential toxicity, its clinical use has diminished. Research continues to explore its pharmacological effects and potential applications in cardiology, aiming to develop safer cardiac medications inspired by natural compounds.