K252c

• CAT Number: R021029
• CAS Number: 85753-43-1
• Molecular Formula: C20H13N3O
• Molecular Weight: 311.34
• Purity: ≥95%
• Synonyms: 6,7,12,13-Tetrahydro-5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one; Antibiotic K 252c; SD 1825; Staurosporine Aglycon; Staurosporinone
• Target: TGF-beta/Smad
• Solubility: >15.6mg/mL in DMSO
• Storage: Store at -20°C
• IUPAC Name: 3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-12-one
• InChI: InChI=1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24)
• InChIKey: MEXUTNIFSHFQRG-UHFFFAOYSA-N
• SMILES: C1C2=C3C4=CC=CC=C4NC3=C5C(=C2C(=O)N1)C6=CC=CC=C6N5

K252c（Cat No.:R021029）is a potent, selective inhibitor of protein kinase activity, primarily targeting receptor tyrosine kinases and cyclin-dependent kinases. Its structural similarity to the natural product staurosporine allows it to effectively modulate various signaling pathways involved in cell proliferation and differentiation. K252c has demonstrated potential in cancer research, particularly in inhibiting tumor growth and inducing apoptosis in various cancer cell lines. Additionally, its role in neurobiology has been explored, showcasing effects on neuronal survival and differentiation. This compound is a valuable tool for understanding kinase-related mechanisms in both cancer and neurodegenerative diseases.