For research use only. Not for therapeutic Use.
K579 is a potent and orally active dipeptidyl peptidase IV inhibitor. K579 inhibits the blood glucose elevation. K579 increases the plasma insulin and active forms of glucagon-like peptide-1 (GLP-1). K579 has the potential for the research of diabetic[1].
Catalog Number | I010633 |
CAS Number | 440100-64-1 |
Synonyms | (2S)-1-[2-[(4-methyl-1-pyrimidin-2-ylpiperidin-4-yl)amino]acetyl]pyrrolidine-2-carbonitrile |
Molecular Formula | C17H24N6O |
Purity | ≥95% |
InChI | InChI=1S/C17H24N6O/c1-17(21-13-15(24)23-9-2-4-14(23)12-18)5-10-22(11-6-17)16-19-7-3-8-20-16/h3,7-8,14,21H,2,4-6,9-11,13H2,1H3/t14-/m0/s1 |
InChIKey | JERPHRNGJBSFAP-AWEZNQCLSA-N |
SMILES | CC1(CCN(CC1)C2=NC=CC=N2)NCC(=O)N3CCCC3C#N |
Reference | [1]. Takasaki K,et al. K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a long-acting hypoglycemic agent. Eur J Pharmacol. 2004 Feb 23;486(3):335-42. |