K6PC-5

For research use only. Not for therapeutic Use.

  • CAT Number: I011936
  • CAS Number: 756875-51-1
  • Molecular Formula: C19H37NO4
  • Molecular Weight: 343.5
  • Purity: ≥95%
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K6PC-5(Cat No.:I011936) is a compound that acts as an activator of sphingosine kinase 1 (SphK1). Sphingosine kinases are enzymes involved in the metabolism of sphingolipids, specifically converting sphingosine into sphingosine-1-phosphate (S1P). By activating SphK1, K6PC-5 enhances the production of S1P, a bioactive lipid with diverse cellular functions. S1P plays a crucial role in various physiological processes, including cell proliferation, migration, and survival. The activation of SphK1 by K6PC-5 represents a potential therapeutic strategy for modulating S1P signaling pathways and exploring its implications in different disease conditions.


Catalog Number I011936
CAS Number 756875-51-1
Synonyms

K6PC-5; K6PC 5; K6PC5;2-Hexyl-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-3-oxo-decanamide

Molecular Formula C19H37NO4
Purity ≥95%
Solubility Soluble in DMSO
Storage -20°C
IUPAC Name N-(1,3-dihydroxypropan-2-yl)-2-hexyl-3-oxodecanamide
InChI InChI=1S/C19H37NO4/c1-3-5-7-9-11-13-18(23)17(12-10-8-6-4-2)19(24)20-16(14-21)15-22/h16-17,21-22H,3-15H2,1-2H3,(H,20,24)
InChIKey CGYVFCHCRBGGJG-UHFFFAOYSA-N
SMILES CCCCCCCC(=O)C(CCCCCC)C(=O)NC(CO)CO
Reference

</br>1: Shao JJ, Peng Y, Wang LM, Wang JK, Chen X. Activation of SphK1 by K6PC-5 Inhibits Oxygen-Glucose Deprivation/Reoxygenation-Induced Myocardial Cell Death. DNA Cell Biol. 2015 Nov;34(11):669-76. doi: 10.1089/dna.2015.2959. Epub 2015 Aug 26. PubMed PMID: 26308910; PubMed Central PMCID: PMC4642826.</br>2: Ji F, Mao L, Liu Y, Cao X, Xie Y, Wang S, Fei H. K6PC-5, a novel sphingosine kinase 1 (SphK1) activator, alleviates dexamethasone-induced damages to osteoblasts through activating SphK1-Akt signaling. Biochem Biophys Res Commun. 2015 Mar 13;458(3):568-75. doi: 10.1016/j.bbrc.2015.02.007. Epub 2015 Feb 11. PubMed PMID: 25680461.</br>3: Kwon YB, Kim CD, Youm JK, Gwak HS, Park BD, Lee SH, Jeon S, Kim BJ, Seo YJ, Park JK, Lee JH. Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation. J Lipid Res. 2007 Sep;48(9):1936-43. Epub 2007 Jun 6. Erratum in: J Lipid Res. 2007 Dec;48(12):2794. PubMed PMID: 17554144.</br>4: Bernacchioni C, Cencetti F, Kwon MJ, Gwak HS, Jeong SK, Bruni P, Donati C. The sphingosine kinase activator K6PC-5 stimulates C2C12 myoblast differentiation. Int J Immunopathol Pharmacol. 2011 Jan-Mar;24(1):55-62. PubMed PMID: 21496387.</br>5: Park HY, Youm JK, Kwon MJ, Park BD, Lee SH, Choi EH. K6PC-5, a novel sphingosine kinase activator, improves long-term ultraviolet light-exposed aged murine skin. Exp Dermatol. 2008 Oct;17(10):829-36. doi: 10.1111/j.1600-0625.2008.00708.x. Epub 2008 Mar 13. PubMed PMID: 18341573.</br>6: Hong JH, Youm JK, Kwon MJ, Park BD, Lee YM, Lee SI, Shin DM, Lee SH. K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signaling. J Invest Dermatol. 2008 Sep;128(9):2166-78. doi: 10.1038/jid.2008.66. Epub 2008 Apr 3. PubMed PMID: 18385762.</br>7: Youm JK, Jo H, Hong JH, Shin DM, Kwon MJ, Jeong SK, Park BD, Choi EH, Lee SH. K6PC-5, a sphingosine kinase activator, induces anti-aging effects in intrinsically aged skin through intracellular Ca2+ signaling. J Dermatol Sci. 2008 Aug;51(2):89-102. doi: 10.1016/j.jdermsci.2008.03.002. Epub 2008 Apr 16. PubMed PMID: 18420384.</br>8: Jung M, Lee S, Park HY, Youm JK, Jeong S, Bae J, Kwon MJ, Park BD, Lee SH, Choi EH. Anti-ageing effects of a new synthetic sphingolipid (K6EAA-L12) on aged murine skin. Exp Dermatol. 2011 Apr;20(4):314-9. doi: 10.1111/j.1600-0625.2010.01185.x. Epub 2011 Mar 1. PubMed PMID: 21366697.</br>9: Xu L, Zhang Y, Gao M, Wang G, Fu Y. Concurrent targeting Akt and sphingosine kinase 1 by A-674563 in acute myeloid leukemia cells. Biochem Biophys Res Commun. 2016 Apr 15;472(4):662-8. doi: 10.1016/j.bbrc.2016.02.094. Epub 2016 Feb 23. PubMed PMID: 26920060.</br></br>

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