KAF-156

• CAT Number: I007476
• CAS Number: 1261113-96-5
• Molecular Formula: C22H23F2N5O
• Molecular Weight: 411.46
• Purity: ≥95%
• Synonyms: KAF-156; KAF 156; KAF156; GNF-156; GNF156; GNF 156.;2-Amino-1-(2-(4-fluorophenyl)-3-((4-fluorophenyl)amino)-5,6-dihydro-8,8-dimethylimidazo(1,2-a)pyrazin-7(8H)-yl)ethanone
• Target: Parasite
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term , or -20°C for long term.
• IUPAC Name: 2-amino-1-[3-(4-fluoroanilino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7-yl]ethanone
• InChI: InChI=1S/C22H23F2N5O/c1-22(2)21-27-19(14-3-5-15(23)6-4-14)20(26-17-9-7-16(24)8-10-17)28(21)11-12-29(22)18(30)13-25/h3-10,26H,11-13,25H2,1-2H3
• InChIKey: BUPRVECGWBHCQV-UHFFFAOYSA-N
• SMILES: CC1(C2=NC(=C(N2CCN1C(=O)CN)NC3=CC=C(C=C3)F)C4=CC=C(C=C4)F)C

KAF-156（Cat No.:I007476）is an investigational drug developed as a potent and selective inhibitor of the plasmodial folate synthesis pathway, specifically targeting the enzyme dihydrofolate reductase (DHFR) in the malaria parasite. By inhibiting DHFR, KAF-156 disrupts the parasite’s ability to synthesize essential folate metabolites, leading to its death. This compound has shown promising preclinical and early clinical results in treating malaria, particularly in cases resistant to other treatments. KAF-156 is being evaluated for its potential as a novel therapy to combat malaria, especially in regions with drug-resistant strains. Further trials are needed for confirmation.