Kakkalide

• CAT Number: R072575
• CAS Number: 58274-56-9
• PubChem Substance ID: 5490351
• Molecular Formula: C28H32O15
• Molecular Weight: 608.549
• Purity: ≥95%
• Synonyms: 5-hydroxy-6-methoxy-3-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one; DTXSID10207003; HY-N4244.
• Target: NF-κB
• IUPAC Name: 5-hydroxy-6-methoxy-3-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
• InChI: InChI=1S/C28H32O15/c1-37-12-5-3-11(4-6-12)13-8-39-15-7-16(26(38-2)22(33)18(15)19(13)30)42-28-25(36)23(34)21(32)17(43-28)10-41-27-24(35)20(31)14(29)9-40-27/h3-8,14,17,20-21,23-25,27-29,31-36H,9-10H2,1-2H3/t14-,17-,20+,21-,23+,24-,25-,27+,28-/m1/s1
• InChIKey: QTVAYNGFFDZGDR-CIJVEFAYSA-N
• SMILES: COC1=CC=C(C=C1)C2=COC3=CC(=C(C(=C3C2=O)O)OC)OC4C(C(C(C(O4)COC5C(C(C(CO5)O)O)O)O)O)O

Kakkalide is a flavonoid glycoside primarily found in the flower buds of Pueraria thunbergiana, known for its antioxidant, anti-inflammatory, and hepatoprotective properties. It is metabolized into kakkalidone and irisolidone in the body, compounds that contribute to its therapeutic effects. Kakkalide has been studied for its potential to protect the liver from damage, reduce oxidative stress, and alleviate symptoms of alcohol-induced hangovers. Its diverse biological activities make it a promising compound in traditional medicine and modern therapeutic applications.