Kamebakaurin

• CAT Number: I016776
• CAS Number: 73981-34-7
• Molecular Formula: C₂₀H₃₀O₅
• Molecular Weight: 350.45
• Purity: ≥95%
• Target: NF-κB
• IUPAC Name: (1R,2R,4R,8S,9R,10S,13S,16R)-2,8,16-trihydroxy-9-(hydroxymethyl)-5,5-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecan-15-one
• InChI: InChI=1S/C20H30O5/c1-10-11-4-5-12-19(9-21)13(18(2,3)7-6-14(19)22)8-15(23)20(12,16(10)24)17(11)25/h11-15,17,21-23,25H,1,4-9H2,2-3H3/t11-,12-,13+,14-,15+,17+,19-,20-/m0/s1
• InChIKey: WHSUEVLJUHPROF-BIGDWJEQSA-N
• SMILES: CC1(CC[C@@H]([C@@]2([C@@H]1C[C@H]([C@]34[C@H]2CC[C@H]([C@H]3O)C(=C)C4=O)O)CO)O)C

Kamebakaurin（Cat No.:I016776）is a naturally occurring diterpenoid compound found in Isodon japonicus, a plant used in traditional medicine. It has demonstrated notable bioactivity, particularly in the fields of oncology and inflammation. Kamebakaurin exhibits potent anticancer effects, inhibiting the growth of various cancer cell lines by inducing apoptosis and cell cycle arrest. Additionally, it has anti-inflammatory properties, which make it a candidate for the treatment of conditions like rheumatoid arthritis. Its mechanisms of action include the modulation of signaling pathways involved in cell survival and inflammation. Further research is needed to explore its therapeutic potential.

Reference

[1]. Lee JH, et al. Kaurane diterpene, kamebakaurin, inhibits NF-kappa B by directly targeting the DNA-binding activity of p50 and blocks the expression of antiapoptotic NF-kappa B target genes. J Biol Chem. 2002 May 24;277(21):18411-20.