For research use only. Not for therapeutic Use.
KAN0438757 (Cat No.:I019095) is a highly potent and selective inhibitor of the metabolic kinase PFKFB3, also known as 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3. It exhibits strong inhibitory activity against PFKFB3 with an IC50 value of 0.19 μM. Additionally, it displays moderate inhibition of PFKFB4 with an IC50 value of 3.6 μM. By specifically targeting PFKFB3, KAN0438757 has the potential to modulate glucose metabolism and affect cellular energy homeostasis.
| Catalog Number | I019095 |
| CAS Number | 1451255-59-6 |
| Molecular Formula | C₂₁H₁₈FNO₇S |
| Purity | ≥95% |
| Target | Autophagy |
| Storage | Store at -20°C |
| IUPAC Name | 2-hydroxyethyl 4-[[3-(5-fluoro-2-hydroxyphenyl)phenyl]sulfonylamino]-2-hydroxybenzoate |
| InChI | InChI=1S/C21H18FNO7S/c22-14-4-7-19(25)18(11-14)13-2-1-3-16(10-13)31(28,29)23-15-5-6-17(20(26)12-15)21(27)30-9-8-24/h1-7,10-12,23-26H,8-9H2 |
| InChIKey | QRDFCYMUXHUTCS-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC(=C1)S(=O)(=O)NC2=CC(=C(C=C2)C(=O)OCCO)O)C3=C(C=CC(=C3)F)O |
