KAR2

• CAT Number: H000085
• CAS Number: 857054-03-6
• Molecular Formula: C7H4O3
• Molecular Weight: 136.11
• Purity: ≥95%
• Synonyms: 2H-furo[2,3-c]pyran-2-one
• Storage: Store at 0-8 °C
• IUPAC Name: furo[2,3-c]pyran-2-one
• InChI: InChI=1S/C7H4O3/c8-7-3-5-1-2-9-4-6(5)10-7/h1-4H
• InChIKey: OBHRCUWVUFZNMG-UHFFFAOYSA-N
• SMILES: C1=COC=C2C1=CC(=O)O2

KAR2(Cat No.:H000085), also known as BiP or GRP78, is a key molecular chaperone in the endoplasmic reticulum (ER) of eukaryotic cells. It plays a vital role in protein folding, quality control, and stress response within the ER. By binding to misfolded proteins, KAR2 prevents their aggregation and assists in their proper folding and assembly. It is essential in maintaining cellular homeostasis and is involved in the unfolded protein response (UPR). KAR2’s function is crucial in studying diseases related to protein misfolding and ER stress, such as neurodegenerative disorders and cancer.