Karanjin

• CAT Number: M004968
• CAS Number: 521-88-0
• Molecular Formula: C18H12O4
• Molecular Weight: 292.29
• Purity: ≥95%
• Synonyms: 3-METHOXY-2-PHENYL-4H-FURO[2,3-H]-1-BENZOPYRAN-4-ONE;KARANJIN;karanjin from pongamia glabra oil;2-Phenyl-3-methoxy-4H-furo[2,3-h]-1-benzopyran-4-one;Kranjin;3-methoxy-2-phenyl-furo[2,3-h]chromen-4-one;3-methoxy-2-phenylfuro[2,3-h]chromen-4-one;NSC 33
• Target: PI3K/Akt/mTOR
• Storage: -20°C
• IUPAC Name: 3-methoxy-2-phenylfuro[2,3-h]chromen-4-one
• InChI: InChI=1S/C18H12O4/c1-20-18-15(19)13-7-8-14-12(9-10-21-14)17(13)22-16(18)11-5-3-2-4-6-11/h2-10H,1H3
• InChIKey: LKPQNZRGGNOPPU-UHFFFAOYSA-N
• SMILES: COC1=C(OC2=C(C1=O)C=CC3=C2C=CO3)C4=CC=CC=C4

Karanjin（Cat No.:M004968）is a flavonoid compound derived from the seeds of the Pongamia pinnata tree, known for its diverse biological activities. It exhibits significant antioxidant, anti-inflammatory, and antimicrobial properties, making it a candidate for various therapeutic applications. Research indicates that karanjin can inhibit tumor growth and enhance liver function, contributing to its potential in cancer and liver disease treatment. Additionally, it has shown promise in promoting skin health and wound healing. Its multifunctional nature highlights its importance in natural product research and the development of phytopharmaceuticals. 

Reference

1: Michaelis M, Rothweiler F, Nerreter T, Sharifi M, Ghafourian T, Cinatl J.
Karanjin interferes with ABCB1, ABCC1, and ABCG2. J Pharm Pharm Sci.
2014;17(1):92-105. PubMed PMID: 24735762.

2: Mandal B, Maity CR. Hypoglycemic action of karanjin. Acta Physiol Pharmacol
Bulg. 1986;12(4):42-6. PubMed PMID: 3577798.

3: Jaiswal N, Yadav PP, Maurya R, Srivastava AK, Tamrakar AK. Karanjin from
Pongamia pinnata induces GLUT4 translocation in skeletal muscle cells in a
phosphatidylinositol-3-kinase-independent manner. Eur J Pharmacol. 2011 Nov
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4: Bose M, Chakraborty M, Bhattacharya S, Mukherjee D, Mandal S, Mishra R.
Prevention of arthritis markers in experimental animal and inflammation
signalling in macrophage by Karanjin isolated from Pongamia pinnata seed extract.
Phytother Res. 2014 Aug;28(8):1188-95. doi: 10.1002/ptr.5113. Epub 2014 Jan 7.
PubMed PMID: 24399783.

5: Vismaya, Belagihally SM, Rajashekhar S, Jayaram VB, Dharmesh SM, Thirumakudalu
SK. Gastroprotective Properties of Karanjin from Karanja (Pongamia pinnata)
Seeds; Role as Antioxidant and H, K-ATPase Inhibitor. Evid Based Complement
Alternat Med. 2011;2011:747246. doi: 10.1093/ecam/neq027. Epub 2011 Mar 13.
PubMed PMID: 21799691; PubMed Central PMCID: PMC3137509.

6: Guo JR, Chen QQ, Lam CW, Zhang W. Effects of karanjin on cell cycle arrest and
apoptosis in human A549, HepG2 and HL-60 cancer cells. Biol Res. 2015 Jul
26;48:40. doi: 10.1186/s40659-015-0031-x. PubMed PMID: 26209237; PubMed Central
PMCID: PMC4515023.

7: Katekhaye S, Kale MS, Laddha KS. Development and Validation of an HPLC Method
for Karanjin in Pongamia pinnata linn. Leaves. Indian J Pharm Sci. 2012
Jan;74(1):72-5. doi: 10.4103/0250-474X.102547. PubMed PMID: 23204626; PubMed
Central PMCID: PMC3507349.